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Mutation Information
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Mutation Site
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M204I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
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rt.M204I+rt.M204V;rt.M204I;rt.M204V+rt.M204I;rt.M250L+rt.M250I+rt.M250V+rt.S202C+rt.S202G+rt.T184I+rt.T184S+rt.T184A+rt.T184L+rt.T184F+rt.T184G+rt.M204I+rt.M204V;rt.S202C+rt.S202G+rt.T184I+rt.T184S+rt.T184A+rt.T184L+rt.T184F+rt.T184G+rt.M204I+rt.M204V;rt.M250L+rt.M250I+rt.M250V+rt.M204I+rt.M204V;rt.M204I+rt.M204V+rt.N236T+rt.A181V;rt.A181V+rt.M204I+rt.M204V;rt.N236T+rt.M204I+rt.M204V;rt.M250L+rt.M250I+rt.M250V+rt.S202C+rt.S202G+rt.T184I+rt.T184S+rt.T184A+rt.T184L+rt.T184F+rt.T184G+rt.M204I+rt.M204V+rt.N236T+rt.A181V;rt.M204I+rt.A181V;rt.M204I+rt.A181V+rt.L80I |
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Genotype/Subtype
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B;C |
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Relevant Drug
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lamivudine (LAM);entecavir (ETV) |
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Country
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China |
Literature Information
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PubMed PMID
|
27792585
|
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Disease
|
HBV infection
|
|
Published Year
|
2017 |
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Journal
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Microbial drug resistance (Larchmont, N.Y.) |
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Title
|
Comparison of Detection Rate and Mutational Pattern of Drug-Resistant Mutations Between a Large Cohort of Genotype B and Genotype C Hepatitis B Virus-Infected Patients in North China. |
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Author
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Li X,Liu Y,Xin S,Ji D,You S,Hu J,Zhao J,Wu J,Liao H,Zhang XX,Xu D |
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Evidence
|
For entecavir-resistant mutations, HBV/C-infected patients had a higher detection rate of rtM204 V/I+T184 substitution or S202G/C (3.66% vs. 2.16%, p < 0.01) and a lower detection rate of rtM204 V/I+M250 V/I/L substitution (0.67% vs. 1.46%, p < 0.01).
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HBV Mutation Detail Information