HBV Mutation Detail Information

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Mutation Information

Mutation Site	L180M
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	D
Relevant Drug	lamivudine (LAM);tenofovir (TDF)

Literature Information

PubMed PMID	21159112
Disease	Liver cirrhosis
Published Year	2011
Journal	Transplant infectious disease : an official journal of the Transplantation Society
Title	Prevention of lamivudine-resistant hepatitis B recurrence after liver transplantation with entecavir plus tenofovir combination therapy and perioperative hepatitis B immunoglobulin only.
Author	Karlas T,Hartmann J,Weimann A,Maier M,Bartels M,Jonas S,Mössner J,Berg T,Tillmann HL,Wiegand J
Evidence	A 48-year-old male patient with hepatitis B-induced decompensatedLiver cirrhosis initially improved on lamivudine (LAM) until LAM resistance (rtL180M and rtM204V) emerged followed by renewed decompensation.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation