|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
14760897
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2003 |
|
Journal
|
Antiviral therapy |
|
Title
|
Monitoring the emergence of hepatitis B virus polymerase gene variants during lamivudine therapy in human immunodeficiency virus coinfected patients: performance of CLIP sequencing and line probe assay. |
|
Author
|
Roque-Afonso AM,Férey MP,Mackiewicz V,Fki L,Dussaix E |
|
Evidence
|
Interestingly, TRUGENE sequencing identified on late samples from three patients a variant carrying rtV173L plus rtL180M plus M204V mutations, having the in vitro characteristics of 'vaccine escape' mutants.
|
|
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HBV Mutation Detail Information