|
Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.S202G+rt.M204V+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM);entecavir (ETV) |
Literature Information
|
PubMed PMID
|
17935165
|
|
Disease
|
HBV infection
|
|
Published Year
|
2007 |
|
Journal
|
Journal of medical virology |
|
Title
|
Successful treatment of an entecavir-resistant hepatitis B virus variant. |
|
Author
|
Yatsuji H,Hiraga N,Mori N,Hatakeyama T,Tsuge M,Imamura M,Takahashi S,Fujimoto Y,Ochi H,Abe H,Maekawa T,Suzuki F,Kumada H,Chayama K |
|
Evidence
|
In conclusion, this study showed that virological and biochemical breakthrough due to ETV could occur in patients infected with LAM-resistant HBV and confirmed that the addition of rtS202G substitution to the rtL180M + M204V mutant strain is responsible for ETV resistance and we could treat the resistant mutant successfully.
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HBV Mutation Detail Information