|
Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M+rt.L229V;rt.M204V+rt.L180M+rt.L229M |
|
Amino acid_Mutation
|
A739G |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
china |
Literature Information
|
PubMed PMID
|
33124952
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2020 |
|
Journal
|
Emerging microbes & infections |
|
Title
|
Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients. |
|
Author
|
Fu Y,Wu S,Hu Y,Chen T,Zeng Y,Liu C,Ou Q |
|
Evidence
|
It contributed to the most potent suppression of viral replication and reduced the in-vitro drug susceptibility to entecavir (ETV) when coexisting with rtM204V, consistent with the hypothesis based on the molecular modeling and clinical data analysis.
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|
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HBV Mutation Detail Information