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Mutation Information
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Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M |
|
Genotype/Subtype
|
D |
|
Relevant Drug
|
lamivudine (LAM);adefovir (ADV) |
Literature Information
|
PubMed PMID
|
12500185
|
|
Published Year
|
2003 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Effect of the G1896A precore mutation on drug sensitivity and replication yield of lamivudine-resistant HBV in vitro. |
|
Author
|
Chen RY,Edwards R,Shaw T,Colledge D,Delaney WE 4th,Isom H,Bowden S,Desmond P,Locarnini SA |
|
Evidence
|
HBV baculoviruses encoding the G1896A PC stop codon mutation were generated in wild-type (WT) and lamivudine-resistant (rtM204I and rtL180M + rtM204V) backgrounds, resulting in a panel of 6 related recombinant baculoviruses.
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HBV Mutation Detail Information