HBV Mutation Detail Information

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Mutation Information
Mutation Site L80I
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Combined Mutation rt.L80I+rt.M204I
Relevant Drug lamivudine (LAM)
Country beijing;China
Literature Information
PubMed PMID 22398037
Disease Chronic hepatitis B
Published Year 2012
Journal Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Title The rtL229 substitutions in the reverse transcriptase region of hepatitis B virus (HBV) polymerase are potentially associated with lamivudine resistance as a compensatory mutation.
Author Ji D,Liu Y,Li L,Xu Z,Si LL,Dai JZ,Li X,Wang L,Yao Z,Xin SJ,Chen GF,Xu D
Evidence The rtM204I, rtM204I + L229F, and rtM204I + L80I strains were all dramatically resistant to LAM, but remained susceptible to ADV, ETV, and TDF.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation