|
Mutation Information
|
Mutation Site
|
V173L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.V173L+rt.L180M+rt.M204I+rt.M204V;rt.L80I+rt.V173L+rt.L180M+rt.M204I;rt.L80I+rt.V173L+rt.M204I |
|
Viral Reference
|
X70185
|
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
17913933
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2007 |
|
Journal
|
Journal of clinical microbiology |
|
Title
|
Evolution of primary and compensatory lamivudine resistance mutations in chronic hepatitis B virus-infected patients during long-term lamivudine treatment, assessed by a line probe assay. |
|
Author
|
Libbrecht E,Doutreloigne J,Van De Velde H,Yuen MF,Lai CL,Shapiro F,Sablon E |
|
Evidence
|
After 36 months, a compensatory mutation was seen at position rt173 (V173L) in 3/15 patients.
|
|
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HBV Mutation Detail Information