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Mutation Information
|
Mutation Site
|
M250I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
A;B;C;D |
|
Relevant Drug
|
entecavir (ETV) |
|
Country
|
Canada;Italy;China;United States |
Literature Information
|
PubMed PMID
|
29713126
|
|
Published Year
|
2018 |
|
Journal
|
World journal of gastroenterology |
|
Title
|
Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression. |
|
Author
|
Choi YM,Lee SY,Kim BJ |
|
Evidence
|
For example, using direct sequencing of samples from treatment-naïve patients from the United States, Nguyen et al[45] demonstrated that only four (0.9%) of 472 patients were infected with viruses with primary and secondary mutations (rtA181A/S, rtA194S, and rtM250I).
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HBV Mutation Detail Information