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Mutation Information
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Mutation Site
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M129L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Combined Mutation
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rt.M204I+rt.V173L+rt.M129L;rt.H337N+rt.M204I+rt.V173L+rt.M129L |
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Genotype/Subtype
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C2 |
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Country
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South Korea |
Literature Information
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PubMed PMID
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26322642
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Published Year
|
2015 |
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Journal
|
PloS one |
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Title
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Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance. |
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Author
|
Ahn SH,Kim DH,Lee AR,Kim BK,Park YK,Park ES,Ahn SH,Shin GC,Park S,Kang HS,Rhee JK,Yang SI,Chong Y,Kim KH |
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Evidence
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Southern blot analysis of four mutants (rtM204I, rtV173L+M204I, rtM129L+V173L+M204I, and rtM129L+V173L+M204I+H337N) was performed to determine the replicative capacity of each clone compared to the WT virus (Fig 2B).
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HBV Mutation Detail Information