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Mutation Information
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Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M;rt.L180M+rt.M204V |
|
Relevant Drug
|
entecavir (ETV);adefovir (ADV);telbivudine (LDT);tenofovir (TDF);lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
30202825
|
|
Disease
|
HBV infection
|
|
Published Year
|
2018 |
|
Journal
|
Hepatology communications |
|
Title
|
Discovery of the Novel Entecavir-Resistant Hepatitis B Virus Reverse Transcriptase A181C Substitution From an Integrated Genotypic Analysis. |
|
Author
|
Rose RE,Hernandez D,Falk PJ,Ericson K,Zhou N,Thiry A,McPhee F |
|
Evidence
|
One LVD-experienced patient-derived HBV RT harboring LVDr substitutions rtL180M+rtM204V with rtA181C displayed reduced ETV susceptibility (122-fold greater than wild-type HBV) and remained susceptible to adefovir and tenofovir.
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HBV Mutation Detail Information