|
Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.S202I+rt.T184G+rt.L180M;rt.V173L+rt.M204V+rt.L180M;rt.M204V+rt.L180M+rt.V173L+rt.I169T |
|
Genotype/Subtype
|
D |
|
Relevant Drug
|
lamivudine (LAM);entecavir (ETV) |
Literature Information
|
PubMed PMID
|
18571815
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2008 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance. |
|
Author
|
Preiss S,Littlejohn M,Angus P,Thompson A,Desmond P,Lewin SR,Sasadeusz J,Matthews G,Dore GJ,Shaw T,Sozzi V,Yuen L,Lau G,Ayres A,Thio C,Avihingsanon A,Ruxrungtham K,Locarnini S,Revill PA |
|
Evidence
|
LMV resistance was defined by the presence of either rtM204V or rtM204I pol mutations in the dominant HBV species detected by population-based PCR sequencing.
|
|
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HBV Mutation Detail Information