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Mutation Information
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Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204I+rt.L180M;rt.M204I+rt.M204V+rt.L180M;rt.M204I+rt.A181T |
|
Genotype/Subtype
|
B;C |
|
Relevant Drug
|
lamivudine (LAM);telbivudine (LDT) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
26612031
|
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Disease
|
HBV infection
|
|
Published Year
|
2015 |
|
Journal
|
Scientific reports |
|
Title
|
Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China. |
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Author
|
Zhang Q,Liao Y,Chen J,Cai B,Su Z,Ying B,Lu X,Tao C,Wang L |
|
Evidence
|
As shown in Table 2, ADV-associated mutation rtA181V/T/S demonstrated a remarkable higher prevalence in genotype C than genotype B (13.5% vs. 5.1%, P < 0.001), and so did other mutations (rtN/H238T P < 0.001, rtP237H P = 0.002, and rtV214A P = 0.006). Nevertheless, LMV-associated mutation rtM204V/I and rtL180M, LdT-associated mutation rtM204I, and ETV-associated mutations rtT184A/I/S, rtS202G and rtM250L didn’t differ significantly between genotype B and C (P > 0.05).
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HBV Mutation Detail Information