HBV Mutation Detail Information

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Mutation Information
Mutation Site L180M
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Combined Mutation rt.V173L+rt.L180M+rt.M204I+rt.M204V;rt.L80I+rt.V173L+rt.L180M+rt.M204I
Viral Reference X70185
Relevant Drug lamivudine (LAM)
Country China
Literature Information
PubMed PMID 17913933
Disease Chronic hepatitis B
Published Year 2007
Journal Journal of clinical microbiology
Title Evolution of primary and compensatory lamivudine resistance mutations in chronic hepatitis B virus-infected patients during long-term lamivudine treatment, assessed by a line probe assay.
Author Libbrecht E,Doutreloigne J,Van De Velde H,Yuen MF,Lai CL,Shapiro F,Sablon E
Evidence In all 20 patients, the mutation occurred in the YMDD motif at reverse transcriptase position 204 (rt204; M204V/I) either with or without the compensatory mutation at position rt180 (L180M).

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation