HBV Mutation Detail Information

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Mutation Information

Mutation Site	A181T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	D
Relevant Drug	adefovir (ADV)
Country	Germany

Literature Information

PubMed PMID	22892524
Disease	HBV infection
Published Year	2012
Journal	Antiviral therapy
Title	Evolution of adefovir-resistant HBV polymerase gene variants after switching to tenofovir disoproxil fumarate monotherapy.
Author	van Bömmel F,Trojan J,Deterding K,Wedemeyer H,Wasmuth HE,Hüppe D,Möller B,Bock FJ,Feucht HH,Berg T
Evidence	METHODS: In 10 HBV-monoinfected patients (9 male, mean age 47 +/-11 [range 27-67] years, 6 hepatitis B e antigen-positive) with virological breakthrough during ADV treatment associated with the mutations rtN236T and/or rtA181T/V, HBV polymerase gene variants were studied during up to 24 months of consecutive monotherapy with TDF by population sequencing, line probe assay and clonal analysis.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation