|
Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.N236T+rt.M204V+rt.A181V+rt.L180M+rt.V173L;rt.M204V+rt.T184I+rt.L180M;rt.M204V+rt.L180M;rt.M204V+rt.A200V+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM);adefovir (ADV);hepatitis B immunoglobulin (HBIG) |
|
Country
|
Haiti |
Literature Information
|
PubMed PMID
|
17030194
|
|
Disease
|
Chronic hepatitis B;
Liver cirrhosis
|
|
Published Year
|
2006 |
|
Journal
|
Gastroenterology |
|
Title
|
Selection of a multiple drug-resistant hepatitis B virus strain in a liver-transplanted patient. |
|
Author
|
Villet S,Pichoud C,Villeneuve JP,Trépo C,Zoulim F |
|
Evidence
|
By month 18, the rise in viral load was associated with the emergence of multiple mutations in the RT gene: 15% of HBV clones harbored the rtL180M+T184I+M204V mutations, 20% the rtL180M+A200V+M204V mutations, and interestingly 40% of the viral population harbored the rtL180M+A181V mutations without mutation at the rtM204 codon.
|
|
|
HBV Mutation Detail Information