HBV Mutation Detail Information

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Mutation Information
Mutation Site L180M
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Combined Mutation rt.S202G+rt.M204V+rt.L180M
Genotype/Subtype A;C
Relevant Drug lamivudine (LAM);tenofovir (TDF);adefovir (ADV)
Literature Information
PubMed PMID 26515673
Disease Chronic hepatitis B
Published Year 2016
Journal The Journal of infection
Title Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones.
Author Murakami E,Tsuge M,Hiraga N,Kan H,Uchida T,Masaki K,Nakahara T,Ono A,Miki D,Kawaoka T,Abe H,Imamura M,Aikata H,Ochi H,Hayes CN,Akita T,Tanaka J,Chayama K
Evidence RESULTS: TDF susceptibilities of lamivudine-resistant clones (rtL180M/M204V) and lamivudine plus entecavir-resistant clones (rtL180M/S202G/M204V) were similar to wild type clones in vitro.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation