HBV Mutation Detail Information

> M204I Search Result


Mutation Information
Mutation Site M204I
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Combined Mutation rt.M204I+rt.T184L+rt.L180M
Genotype/Subtype C
Relevant Drug entecavir (ETV)
Country China
Literature Information
PubMed PMID 19125938
Disease Chronic hepatitis B
Published Year 2009
Journal Hepatology research : the official journal of the Japan Society of Hepatology
Title Spontaneous HBeAg seroconversion and loss of hepatitis B virus DNA after acute flare due to development of drug resistant mutants during entecavir monotherapy.
Author Mao RC,Yin YK,Qin YL,Wu XH,Weng XH,Zhang JM,Lu M
Evidence Interestingly, a new mutant type with rtL180M+rtT184L was found alongside rtL180M+rtT184L+rtM204V/I at week 228 and appeared to develop independently, according to the sequence analysis.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation