|
Mutation Information
|
Mutation Site
|
A181T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.N236T+rt.A181T |
|
Relevant Drug
|
adefovir (ADV) |
Literature Information
|
PubMed PMID
|
16729316
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2006 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Increased risk of adefovir resistance in patients with lamivudine-resistant chronic hepatitis B after 48 weeks of adefovir dipivoxil monotherapy. |
|
Author
|
Lee YS,Suh DJ,Lim YS,Jung SW,Kim KM,Lee HC,Chung YH,Lee YS,Yoo W,Kim SO |
|
Evidence
|
In conclusion, the emergence of the rtA181V/T and rtN236T mutations was more common in LAM-resistant patients than in treatment-naive patients after 48 weeks of ADV therapy and was associated with reduced antiviral efficacy to drug treatment.
|
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HBV Mutation Detail Information