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Mutation Information
|
Mutation Site
|
V173L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.V173L+rt.M204V+rt.L180M |
|
Genotype/Subtype
|
B;C |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
26612031
|
|
Disease
|
HBV infection
|
|
Published Year
|
2015 |
|
Journal
|
Scientific reports |
|
Title
|
Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China. |
|
Author
|
Zhang Q,Liao Y,Chen J,Cai B,Su Z,Ying B,Lu X,Tao C,Wang L |
|
Evidence
|
The most common drug resistant mutation model was dual mutation rtL180M+rtM204V, followed by rtL180M+rtM204I. The frequency of LMV-associated mutation models, like rtL180M+rtM204V and rtL180M+rtM204V+rtV173L, showed no statistical difference, except rtL180M+rtM204I, the frequency of which was higher in genotype C than genotype B (10.7% vs. 4.2%, P = 0.026).
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HBV Mutation Detail Information