|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
France |
Literature Information
|
PubMed PMID
|
15618847
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2004 |
|
Journal
|
European journal of gastroenterology & hepatology |
|
Title
|
Long-term therapy with lamivudine in renal transplant recipients with chronic hepatitis B. |
|
Author
|
Thabut D,Thibault V,Bernard-Chabert B,Mouquet C,Di Martino V,Le Calvez S,Opolon P,Benhamou Y,Bitker MO,Poynard T |
|
Evidence
|
Analysis of HBV sequencing after breakthrough revealed specific resistance mutations in both the B and C domains of the polymerase (rtL180M/M204V, n = 5; rtM204I, n = 2).
|
|
|
HBV Mutation Detail Information