|
Mutation Information
|
Mutation Site
|
S202G |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.S202G+rt.A181S+rt.L180M |
|
Relevant Drug
|
entecavir (ETV) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
25132017
|
|
Disease
|
HBV infection
|
|
Published Year
|
2015 |
|
Journal
|
Journal of viral hepatitis |
|
Title
|
The rtA181S mutation of hepatitis B virus primarily confers resistance to adefovir dipivoxil. |
|
Author
|
Liu Y,Li X,Xin S,Xu Z,Chen R,Yang J,Liu L,Wong VW,Yang D,Chan HL,Xu D |
|
Evidence
|
HBV DNA level was significantly inhibited for the duration until virologic and biochemical breakthroughs occurred with the emergence of overwhelming ETV‐resistant strain rtL180M+A181S+S202G+M204V (S8).
|
|
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HBV Mutation Detail Information