|
Mutation Information
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Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
26220282
|
|
Published Year
|
2015 |
|
Journal
|
BMC complementary and alternative medicine |
|
Title
|
Inhibitory effect of Phyllanthus urinaria L. extract on the replication of lamivudine-resistant hepatitis B virus in vitro. |
|
Author
|
Jung J,Kim NK,Park S,Shin HJ,Hwang SG,Kim K |
|
Evidence
|
METHODS: HBV harboring LMV-resistant mutations (rtM204I, rtM204V, and rtM204S) in the P gene at the YMDD ((203)tyrosine-methionine-aspartate-aspartate(206)) reverse transcriptase (RT) active site were generated and their sensitivity to Phyllanthus urinaria koreanis extract examined.
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HBV Mutation Detail Information