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Mutation Information
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Mutation Site
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M204I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Relevant Drug
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lamivudine (LAM);adefovir (ADV);telbivudine (LDT);entecavir (ETV) |
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Country
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Iran |
Literature Information
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PubMed PMID
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23596461
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Disease
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Hepatocellular carcinoma;
Chronic hepatitis B;
Liver cirrhosis;
Acute hepatitis B;
Fulminant hepatitis B
|
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Published Year
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2013 |
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Journal
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Hepatitis monthly |
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Title
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Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-naïve chronic HBV patients. |
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Author
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Mahabadi M,Norouzi M,Alavian SM,Samimirad K,Azad TM,Saberfar E,Mahmoodi M,Ramezani F,Karimzadeh H,Malekzadeh R,Montazeri G,Nejatizadeh A,Ziaee M,Abedi F,Ataei B,Yaran M,Sayad B,Hossein Somi M,Sarizadeh G,Sanei-Moghaddam I,Mansour-Ghanaei F,Rafatpanah H,Pourhosseingholi MA,Keyvani H,Kalantari E,Saberifiroozi M,Ali Judaki M,Ghamari S,Daram M,Fazeli Z,Goodarzi Z,Khedive A,Moradi A,Jazayeri SM |
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Evidence
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All strains belonging to genotype D.365 amino-acid substitutions were found. Mutations related to lamivudine, adefovir, telbivudine, and entecavir occurred in (YMDD) 4% (n = 13), (SVQ) 17.23% (n = 56), (M204I/V + L180M) 2.45% (n = 8) and (M204I) 2.76% (n = 9) of patients, respectively.
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HBV Mutation Detail Information