|
Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM);adefovir (ADV) |
|
Country
|
Japan |
Literature Information
|
PubMed PMID
|
20367795
|
|
Disease
|
HBV infection
|
|
Published Year
|
2011 |
|
Journal
|
Journal of viral hepatitis |
|
Title
|
Four-year study of lamivudine and adefovir combination therapy in lamivudine-resistant hepatitis B patients: influence of hepatitis B virus genotype and resistance mutation pattern. |
|
Author
|
Inoue J,Ueno Y,Wakui Y,Niitsuma H,Fukushima K,Yamagiwa Y,Shiina M,Kondo Y,Kakazu E,Tamai K,Obara N,Iwasaki T,Shimosegawa T |
|
Evidence
|
An rtA200V mutation was present in the majority of HBV clones, in addition to the 3TC-resistant mutations of rtL180M+M204V.
|
|
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HBV Mutation Detail Information