HBV Mutation Detail Information

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Mutation Information
Mutation Site D205N
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Relevant Drug lamivudine (LAM)
Country USA
Literature Information
PubMed PMID 23114756
Clinical information Yes
Disease HBV infection
Published Year 2013
Journal Antimicrobial agents and chemotherapy
Title Low-level persistence of drug resistance mutations in hepatitis B virus-infected subjects with a past history of Lamivudine treatment.
Author Margeridon-Thermet S,Svarovskaia ES,Babrzadeh F,Martin R,Liu TF,Pacold M,Reuman EC,Holmes SP,Borroto-Esoda K,Shafer RW
Evidence Therefore, following alignment we excluded sequence reads considered to be hypermutated by one of the following three criteria (17): (i) ≥10% of nucleotide positions with a G in the population sequence but an A in the UDPS read, (ii) ≥2 unusual HBV RT variants caused by G-to-A differences (an unusual variant was defined as a variant present in fewer than three sequences from ∼4,000 different individuals with HBV RT sequences in GenBank) (18), or (iii) a stop codon or one of the following active site mutations rtD83N, rtD205N, and rtD206N.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation