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HBV Mutation Detail Information

> L180M Search Result


Mutation Information
Mutation Site L180M
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Genotype/Subtype A
Relevant Drug lamivudine (LAM)
Literature Information
PubMed PMID 18070286
Disease Chronic hepatitis B
Published Year 2007
Journal Journal of viral hepatitis
Title Hepatitis B virus polymerase variants associated with entecavir drug resistance in treatment-naive patients.
Author Jardi R,Rodriguez-Frias F,Schaper M,Ruiz G,Elefsiniotis I,Esteban R,Buti M
Evidence Before therapy, five (4.5%) HBV isolated from the 111 patients presented substitutions in the polymerase gene related with drug resistance to nucleoside analogues, three (2.7%) involving changes associated with ETV resistance (all had the rtS202S/I substitution) and two with lamivudine resistance (rtL180L/M and rtM204M/I).
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation