|
Mutation Information
|
Mutation Site
|
A181T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.N236T+rt.A181T |
|
Genotype/Subtype
|
A;C |
|
Relevant Drug
|
lamivudine (LAM);tenofovir (TDF);adefovir (ADV) |
Literature Information
|
PubMed PMID
|
26515673
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2016 |
|
Journal
|
The Journal of infection |
|
Title
|
Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones. |
|
Author
|
Murakami E,Tsuge M,Hiraga N,Kan H,Uchida T,Masaki K,Nakahara T,Ono A,Miki D,Kawaoka T,Abe H,Imamura M,Aikata H,Ochi H,Hayes CN,Akita T,Tanaka J,Chayama K |
|
Evidence
|
However, lamivudine plus adefovir-resistant clones (rtA181T/N236T) acquired tolerance to TDF, and the rtN236T mutation was considered to be a causal substitution for TDF resistance.
|
|
|
HBV Mutation Detail Information