HBV Mutation Detail Information

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Mutation Information

Mutation Site	M250L
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.M250L+rt.K212T
Relevant Drug	adefovir (ADV);adefovir dipivoxil (ADV)
Country	China

Literature Information

PubMed PMID	19302908
Disease	Chronic hepatitis B
Published Year	2009
Journal	Clinical therapeutics
Title	Evolution of hepatitis B virus polymerase mutations in a patient with HBeAg-positive chronic hepatitis B virus treated with sequential monotherapy and add-on nucleoside/nucleotide analogues.
Author	Wang F,Wang H,Shen H,Meng C,Weng X,Zhang W
Evidence	A total of 20.6% (7/34) of the clones harbored the rtK212T + rtM250L mutation, and rtA181V was found in 2.9% (1/34) of the clones.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation