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Mutation Information
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Mutation Site
|
A1588C |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.C1589T+rt.A1588C |
|
Nucleotide_Mutation
|
T184L |
|
Genotype/Subtype
|
C |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
19125938
|
|
Disease
|
Chronic hepatitis B
|
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Published Year
|
2009 |
|
Journal
|
Hepatology research : the official journal of the Japan Society of Hepatology |
|
Title
|
Spontaneous HBeAg seroconversion and loss of hepatitis B virus DNA after acute flare due to development of drug resistant mutants during entecavir monotherapy. |
|
Author
|
Mao RC,Yin YK,Qin YL,Wu XH,Weng XH,Zhang JM,Lu M |
|
Evidence
|
In HBV_w228, a total of 13 nt substitutions were found, as compared with HBV_w100, leading to 17 aa substitutions (five in HBsAg, 11 in polymerase including the nt substitutions A1588C/C1589T, leading to the rtT184L substitution, and one in the HBx protein).
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HBV Mutation Detail Information