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Mutation Information
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Mutation Site
|
M204I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
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rt.M204V+rt.N236T |
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Relevant Drug
|
lamivudine;telbivudine |
|
Country
|
China |
Literature Information
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PubMed PMID
|
33986897
|
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Disease
|
Chronic hepatitis B
|
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Published Year
|
2021 |
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Journal
|
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale |
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Title
|
High Prevalence of Preexisting HBV Polymerase Mutations in Pregnant Women Does Not Limit the Antiviral Therapy Efficacy. |
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Author
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Wang J,Liu J,Yu Q,Jin L,Yao N,Yang Y,Yan T,Hu C,He Y,Zhao Y,Chen T,Zheng J |
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Evidence
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Results: Before TBV treatment, the complexity of HBV quasispecies of all subjects was 0.40 +- 0.09; 41.1% (30/73) and 53.4% (39/73) subjects had rtM204I/V and rtN236 T/A detected, respectively; and 9.6% (7/73) patients had more than 20% frequency mutation of rtM204I/V, which was also similar with high frequency of rtN236 T/A mutation (41.1% vs.
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HBV Mutation Detail Information