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Mutation Information
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Mutation Site
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M204V |
|
Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
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rt.M204V+rt.L180M;rt.M204I+rt.M204V+rt.L180M;rt.V173L+rt.M204V+rt.L180M;rt.S202G+rt.M204V+rt.L180M;rt.T184L+rt.M204V+rt.L180M;rt.M250L+rt.M204V+rt.L180M |
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Genotype/Subtype
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B;C |
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Relevant Drug
|
lamivudine (LAM) |
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Country
|
China |
Literature Information
|
PubMed PMID
|
26612031
|
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Disease
|
HBV infection
|
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Published Year
|
2015 |
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Journal
|
Scientific reports |
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Title
|
Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China. |
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Author
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Zhang Q,Liao Y,Chen J,Cai B,Su Z,Ying B,Lu X,Tao C,Wang L |
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Evidence
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As shown in Table 2, ADV-associated mutation rtA181V/T/S demonstrated a remarkable higher prevalence in genotype C than genotype B (13.5% vs. 5.1%, P < 0.001), and so did other mutations (rtN/H238T P < 0.001, rtP237H P = 0.002, and rtV214A P = 0.006). Nevertheless, LMV-associated mutation rtM204V/I and rtL180M, LdT-associated mutation rtM204I, and ETV-associated mutations rtT184A/I/S, rtS202G and rtM250L didn’t differ significantly between genotype B and C (P > 0.05).
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HBV Mutation Detail Information