|
Mutation Information
|
Mutation Site
|
L80I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
C |
|
Relevant Drug
|
adefovir (ADV);adefovir dipivoxil (ADV) |
Literature Information
|
PubMed PMID
|
19323782
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2009 |
|
Journal
|
Liver international : official journal of the International Association for the Study of the Liver |
|
Title
|
Hepatitis B virus with the rtL80V/I mutation is associated with a poor response to adefovir dipivoxil therapy. |
|
Author
|
Lee YS,Chung YH,Kim JA,Kim SE,Shin JW,Kim KM,Lim YS,Park NH,Lee HC,Lee YS,Suh DJ |
|
Evidence
|
The rtL80V/I and rtL180M variants were identified in 66 (68%) and 67 (69%) patients respectively.
|
|
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HBV Mutation Detail Information