|
Mutation Information
|
Mutation Site
|
V173L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
20580309
|
|
Disease
|
HBV infection
|
|
Published Year
|
2010 |
|
Journal
|
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology |
|
Title
|
Acute hepatitis B infection associated with drug-resistant hepatitis B virus. |
|
Author
|
Xu Z,Liu Y,Xu T,Chen L,Si L,Wang Y,Ren X,Zhong Y,Zhao J,Xu D |
|
Evidence
|
Direct PCR sequencing showed that 14 samples (7.0%) were positive for drug-resistant HBV variants, comprised of 11 with the lamivudine-resistant pattern rtM204I and/or rtM204V in the presence and absence of compensatory mutations rtL80I, rtV173L, and rtL180M; two with the adefovir-resistant pattern rtA181V; and one with the entecavir-resistant pattern rtL180M+rtS202G+rtM204V.
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HBV Mutation Detail Information