|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204I+rt.L180M;rt.M204V+rt.L180M |
|
Amino acid_Mutation
|
T/C667A |
|
Genotype/Subtype
|
C |
|
Viral Reference
|
X01587
|
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
18713056
|
|
Disease
|
HBV infection
|
|
Published Year
|
2008 |
|
Journal
|
The Journal of infectious diseases |
|
Title
|
Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus. |
|
Author
|
Ohkawa K,Takehara T,Kato M,Deguchi M,Kagita M,Hikita H,Sasakawa A,Kohga K,Uemura A,Sakamori R,Yamaguchi S,Miyagi T,Ishida H,Tatsumi T,Hayashi N |
|
Evidence
|
BACKGROUND: Hepatitis B virus (HBV) establishes lamivudine resistance via the resistance-causative rtM204V/I mutation and the replication-compensatory rtL180M mutation.
|
|
|
HBV Mutation Detail Information