|
Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
A2 |
|
Relevant Drug
|
lamivudine (LAM);adefovir (ADV);entecavir (ETV) |
Literature Information
|
PubMed PMID
|
21696601
|
|
Disease
|
HBV infection
|
|
Published Year
|
2011 |
|
Journal
|
BMC infectious diseases |
|
Title
|
Unsuccessful therapy with adefovir and entecavir-tenofovir in a patient with chronic hepatitis B infection with previous resistance to lamivudine: a fourteen-year evolution of hepatitis B virus mutations. |
|
Author
|
Cassino L,Benetti S,Fay F,Tanno H,Quarleri J |
|
Evidence
|
Once lamivudine therapy was reintroduced, and until entecavir plus tenofovir were administered, the dual lamivudine resistance-associated mutations rtL180M and rtM204I were invariably detected.
|
|
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HBV Mutation Detail Information