HBV Mutation Detail Information

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Mutation Information

Mutation Site	M204V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.L180M+rt.M204V
Genotype/Subtype	C
Viral Reference	AY123043
Relevant Drug	lamivudine (LAM)

Literature Information

PubMed PMID	17854034
Disease	Chronic hepatitis B
Published Year	2007
Journal	Journal of medical virology
Title	Mutational patterns of hepatitis B virus genome and clinical outcomes after emergence of drug-resistant variants during lamivudine therapy: analyses of the polymerase gene and full-length sequences.
Author	Enomoto M,Tamori A,Kohmoto MT,Morikawa H,Habu D,Sakaguchi H,Takeda T,Seki S,Kawada N,Shiomi S,Nishiguchi S
Evidence	The rtM204V mutations were always accompanied by mutations from leucine to methionine at rt180 (rtL180M), while rtM204I mutations were not.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation