Mutation Information
Mutation Site
|
T184I |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Genotype/Subtype
|
D |
Relevant Drug
|
lamivudine (LAM) |
Country
|
Italy |
Literature Information
PubMed PMID
|
23026293
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2012 |
Journal
|
Antiviral research |
Title
|
Genotype-specific mutations in the polymerase gene of hepatitis B virus potentially associated with resistance to oral antiviral therapy. |
Author
|
Mirandola S,Sebastiani G,Rossi C,Velo E,Erne EM,Vario A,Tempesta D,Romualdi C,Campagnolo D,Alberti A |
Evidence
|
In genotype D infected patients, seven mutations at five positions (rtL80I/V, rtV173L, rtL180M, rtT184I, rt204I/V) were significantly associated with LAM therapy (Fisher’s exact test; Benjamini–Hochberg adjusted p value < 0.05).
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