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Mutation Information
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Mutation Site
|
M204V |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
lamivudine (LAM) |
Literature Information
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PubMed PMID
|
11230757
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Published Year
|
2001 |
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Journal
|
Hepatology (Baltimore, Md.) |
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Title
|
Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region. |
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Author
|
Stuyver LJ,Locarnini SA,Lok A,Richman DD,Carman WF,Dienstag JL,Schinazi RF |
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Evidence
|
In this proposal, the HBV rt domain starts with the highly conserved EDWGPCDEHG motif, contains 344 amino acids, and the lamivudine-related resistance mutations are found at amino acid rtL180M (previously amino acid 528, 526, 515, or 525) and rtM204V/I (previously 552, 550, 539, or 549).
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HBV Mutation Detail Information