|
Mutation Information
|
Mutation Site
|
V173L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.L180M+rt.V173L+rt.M204V+rt.M204I |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Turkey |
Literature Information
|
PubMed PMID
|
22224083
|
|
Disease
|
HBV infection
|
|
Published Year
|
2011 |
|
Journal
|
Hepatitis monthly |
|
Title
|
Frequency and mutation patterns of resistance in patients with chronic hepatitis B infection treated with nucleos(t)ide analogs in add-on and switch strategies. |
|
Author
|
Sayan M,Akhan SC,Senturk O |
|
Evidence
|
Four different LAM resistance patterns were identified in 84 out of 194 patients (43%): baseline primary mutation (rtM204I/V, n = 26), primary mutation with the compensatory mutations rtL80I/V (n = 16) or rtL180M (n = 24), triple mutant (rtM204I/V + rtV173L + rtL180M or rtA194G, n = 12), and the single mutation rtL180M (n = 6).
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HBV Mutation Detail Information