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Mutation Information
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Mutation Site
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T184S |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
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rt.M204V+rt.A186T+rt.T184S+rt.L180M;rt.M204V+rt.T184S+rt.L180M |
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Country
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China |
Literature Information
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PubMed PMID
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30796932
|
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Disease
|
HBV infection
|
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Published Year
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2019 |
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Journal
|
Antiviral research |
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Title
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Prevalence of the entecavir-resistance-inducing mutation rtA186T in a large cohort of Chinese hepatitis B virus patients. |
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Author
|
Liu L,Liu Y,Chen R,Li X,Luo D,Zhao Y,Li Q,Huang B,Wang FS,Liu X,Xu D |
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Evidence
|
Compared to wild-type strain, two patient-derived mutants' rtL180M+A186T+M204V and rtL180M+T184S+A186T+M204V had 86.7% and 89.2% decreased replication capacity, 210- and 555-fold increased ETV resistance, respectively; and artificial elimination of rtA186T largely restored their ETV sensitivity.
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HBV Mutation Detail Information