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Mutation Information
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Mutation Site
|
L247F |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
|
Viral Reference
|
U95551
|
Literature Information
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PubMed PMID
|
23261845
|
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Published Year
|
2013 |
|
Journal
|
Antiviral research |
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Title
|
The amino acid substitutions rtP177G and rtF249A in the reverse transcriptase domain of hepatitis B virus polymerase reduce the susceptibility to tenofovir. |
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Author
|
Qin B,Budeus B,Cao L,Wu C,Wang Y,Zhang X,Rayner S,Hoffmann D,Lu M,Chen X |
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Evidence
|
Here, the aa substitutions rtL77F, rtK239E, rtG244Y, rtL247F, and rtG251Y may strongly disturb the polymerase function and led to the complete loss of replication capability of HBV mutants.
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HBV Mutation Detail Information