|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M |
|
Genotype/Subtype
|
A |
|
Viral Reference
|
AF305422
|
|
Relevant Drug
|
lamivudine (LAM);tenofovir (TDF) |
Literature Information
|
PubMed PMID
|
16801428
|
|
Published Year
|
2006 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
Intracellular metabolism and in vitro activity of tenofovir against hepatitis B virus. |
|
Author
|
Delaney WE 4th,Ray AS,Yang H,Qi X,Xiong S,Zhu Y,Miller MD |
|
Evidence
|
The lamivudine-resistant mutant rtL180M+rtM204V HBV displayed a 2.1-fold increase in the EC50 for tenofovir.
|
|
|
HBV Mutation Detail Information