|
Mutation Information
|
Mutation Site
|
A181T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.N236T+rt.A181T |
|
Genotype/Subtype
|
D |
|
Relevant Drug
|
adefovir (ADV) |
|
Country
|
Caucasian |
Literature Information
|
PubMed PMID
|
19065672
|
|
Clinical information
|
Yes
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2009 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Complex dynamics of hepatitis B virus resistance to adefovir. |
|
Author
|
Pallier C,Rodriguez C,Brillet R,Nordmann P,Hézode C,Pawlotsky JM |
|
Evidence
|
UNLABELLED: In patients with hepatitis B e antigen-negativeChronic hepatitis B, adefovir dipivoxil administration selects variants bearing reverse transcriptase rtN236T and/or rtA181V/T substitutions in 29% of cases after 5 years.
|
|
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HBV Mutation Detail Information