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Mutation Information
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Mutation Site
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M250L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Relevant Drug
|
lamivudine (LAM);entecavir (ETV) |
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Country
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China |
Literature Information
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PubMed PMID
|
25493022
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Disease
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HBV infection
|
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Published Year
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2014 |
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Journal
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World journal of gastroenterology |
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Title
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Resistant mutants induced by adefovir dipivoxil in hepatitis B virus isolates. |
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Author
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Jiang SW,Yao LP,Hu AR,Hu YR,Chen SX,Xiong T,Gao GS,Liang XY,Ding SX,Weng PJ |
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Evidence
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Specifically, the following mutations were found: rtL180M, rtM204V, rtV207M/L/I, rtS213T, rtA181T, rtV214A, rtQ215S, rtN236T, rtP237H, rtN238T, rtT184L, and rtM250L. In these mutations, the drug-resistant HBV mutants related to other NUCs such as lamivudine (LAM) and entecavir (ETV) were also found though patients didn’t receive LAM or ETV treatment
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HBV Mutation Detail Information