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Mutation Information
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Mutation Site
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M250L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
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rt.M250L+rt.A181T+rt.L80V+rt.L80I+rt.M204I |
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Country
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China |
Literature Information
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PubMed PMID
|
24160943
|
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Disease
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Chronic hepatitis B
|
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Published Year
|
2013 |
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Journal
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Virology journal |
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Title
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Profile of hepatitis B virus resistance mutations against nucleoside/nucleotide analogue treatment in Chinese patients with chronic hepatitis B. |
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Author
|
Lei J,Wang Y,Wang LL,Zhang SJ,Chen W,Bai ZG,Xu LY |
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Evidence
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According to previously studies, the patterns of genotypic resistance in the HBV polymerase can be categorized into five specific evolutionary pathways [10,11], including L-nucleoside pathway (rtM204I [or V or I/V]), the acyclic phosphonate pathway (rtN236T), the shared pathway (rtA181T [or V or T/V]) of both L-nucleoside and acyclic phosphonate, ETV resistance pathway (rtL180M+rtM204V with one of either rtT184, S202 or M250 residue changes) and multidrug resistance pathways (rtA181T+rtI233V+rtN236T+rtM250L).
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HBV Mutation Detail Information