HBV Mutation Detail Information

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Mutation Information

Mutation Site	N236T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	B
Relevant Drug	adefovir (ADV);adefovir dipivoxil (ADV)

Literature Information

PubMed PMID	26201776
Published Year	2013
Journal	Hepatology international
Title	Hepatitis B virus genotype C encoding resistance mutations that emerge during adefovir dipivoxil therapy: in vitro replication phenotype.
Author	Li W,Warner N,Sozzi V,Yuen L,Colledge D,Li T,Zhuang H,Locarnini S,Revill PA
Evidence	CONCLUSIONS: The identification of secretion-defective HBV in the setting of ADV therapy for HBV genotype C, and to a lesser extent HBV genotype B, has major implications for the diagnosis and treatment of HBV in the Asia-Pacific region, as it is likely that quantitative HBsAg and viral load testing of serum from patients infected with HBV encoding rtA181T and rtN236T substitutions may not accurately reflect the level of replication within hepatocytes.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation