|
Mutation Information
|
Mutation Site
|
A181T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.N236T+rt.A181T |
|
Viral Reference
|
AY090460;
AF160501;
X75657;
X02496;
AB033556;
D00330;
X02763 |
|
Relevant Drug
|
adefovir (ADV) |
|
Country
|
Canada |
Literature Information
|
PubMed PMID
|
16757589
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2006 |
|
Journal
|
Journal of clinical microbiology |
|
Title
|
Detection of rtN236T and rtA181V/T mutations associated with resistance to adefovir dipivoxil in samples from patients with chronic hepatitis B virus infection by the INNO-LiPA HBV DR line probe assay (version 2). |
|
Author
|
Osiowy C,Villeneuve JP,Heathcote EJ,Giles E,Borlang J |
|
Evidence
|
By LiPA analysis, 12 patients (31.5%) were found to have mutations associated with resistance to ADV (rtA181V/T and/or rtN236T).
|
|
|
HBV Mutation Detail Information