HBV Mutation Detail Information

> T184I Search Result


Mutation Information
Mutation Site T184I
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Relevant Drug entecavir (ETV);lamivudine (LAM)
Literature Information
PubMed PMID 17178796
Disease Chronic hepatitis B
Published Year 2007
Journal Antimicrobial agents and chemotherapy
Title Two-year assessment of entecavir resistance in Lamivudine-refractory hepatitis B virus patients reveals different clinical outcomes depending on the resistance substitutions present.
Author Tenney DJ,Rose RE,Baldick CJ,Levine SM,Pokornowski KA,Walsh AW,Fang J,Yu CF,Zhang S,Mazzucco CE,Eggers B,Hsu M,Plym MJ,Poundstone P,Yang J,Colonno RJ
Evidence Consequently, only 2/187 (1%) patients experienced ETVr rebounds in year 1, with an additional 14/151 (9%) patients experiencing ETVr rebounds in year 2. Isolates from all 16 patients with rebounds were LVDr and harbored the T184 and/or S202 change.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation