HBV Mutation Detail Information

> L269I Search Result

Mutation Information

Mutation Site	L269I
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.M204V+rt.L180M+rt.V173L+rt.L269I+rt.D134E+rt.H126Y+rt.S106C;rt.M204I+rt.L180M+rt.L80I+rt.L269I+rt.D134E+rt.H126Y+rt.S106C;rt.L229M+rt.M204I+rt.L269I+rt.D134E+rt.H126Y+rt.S106C;rt.A181V+rt.L269I+rt.D134E+rt.H126Y+rt.S106C;rt.N236T+rt.L269I+rt.D134E+rt.H126Y+rt.S106C

Literature Information

PubMed PMID	32894807
Disease	Chronic hepatitis B
Published Year	2021
Journal	Journal of viral hepatitis
Title	Characterization of Hepatitis B virus polymerase mutations A194T and CYEI and tenofovir disoproxil fumarate or tenofovir alafenamide resistance.
Author	Liu Y,Chang S,Martin R,Flaherty J,Mo H,Feierbach B
Evidence	Both the A194T and a quadruple mutation CYEI (S106C, H126Y, D134E and L269I) in hepatitis B virus (HBV) polymerase reverse transcriptase domain (pol/RT) are suggested to be associated with treatment failure with tenofovir disoproxil fumarate (TDF).

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation